Imaging Probe to Diagnose Cancer within Body

Nowadays, recognizing tissue with cancerous properties inside the body needs a biopsy as well as a review of the removed sample within a pathology lab. A squad of German scientists has been operating towards a method of recognizing tumors utilizing an endoscopic way that does not include ‘essentiality of taking samples’. They have designed a laser-based multi-modality imaging probe that is able of distinguishing types of tissue without using a staining dye.

The probe depends on tremendously fast near-infrared lasers and is 8 mm in diameter. It can generate “nonlinear optical effects” within besieged tissue. Three imaging ways are employed at the same time, namely second harmonic generation, coherent anti-stokes Raman scattering, and two-photon excited auto-fluorescence.

Every type modality is transported to the tilt of the probe individually; thanks to an optical fiber that is multi-core in nature. Furthermore, since there are hundreds of separate optical channels, the gadget is capable of examining across a surface exclusive of depending on unstable mirrors or different mechanical parts having to be incorporated into its tilt. The genuine stirring parts are situated at another end of the optical fibers, permitting the tip to be small.

The light emitting from the lasers is targeted utilizing a novel lens that is 1.8 mm in diameter, which molds the light; thanks to a substance that has a gradient of refractive index throughout it.

They also verified that the probe might obtain individual second harmonic generation, coherent anti-stokes Raman scattering, and two-photon excited auto-fluorescence images of fit human skin tissue samples having a scanned area of 300 x 300 microns for a resolution of 2048 x 2048 pixels. This field of view and resolution is enough for recognizing tumor borders, and the probe can be moved over the surface of the tissue to get a general idea of the area that is affected.

For now, the probe is under examination and needs to be undergone through various tests before it gets commercial. But do expect to see it in the coming years. For now, this is what we all can say about this. Stay tuned for more updates.

Vaibhav Bhosale undertook the post of Content Writer at Medical Device News in November 2016, following a 1.2-year of experience as an Project Lead; Instructional Writer at eNyota Learning Pvt. Ltd. His immense interest in reading brought him in this field. He can be reached at