Human body though seems to be very intact from external looks but internally occurring diseases and inflammation leads to severe consequences. Mainly our digestion system, intestines, and all the parts of the body that do an intricate task of the processing consumed food. Our daily eating habits no matter it is healthy or unhygienic the internal system churns it all. But everything has a limit and after all it human body made up of several tissues. Many of us experience burning in the belly which can be termed as inflammation. Intestinal damage can lead to permanent intake of pro-inflammatory foods for the lifetime.
Linked to the similar issues related to the gut, Researchers at Rice University have hereditarily engineered bacteria to identify the inflammation linked with colitis present the gut. At present stage, to examine the health of the gut directs a patient to mandatorily go through expensive and invasive colonoscopy procedures.
This newly developed bacterial sensor after swallowed can readily generate the report of the gut health of the patients which can help in avoiding the future hazards.
The biologist teams hypothesized that molecule known as thiosulfate is enlarged in the affected part of the gut. They rectified that genes encode for sulfate sensors in bacteria that exist in fluidic deposits. Researchers then made a bacterium by genetically altering the E.coli to transmit the genes that as a result produces a green fluorescent protein in the existence of the thiosulfate.
The bacteria sensor was given to healthy mice and mice with colitis orally. Further, the Mice with the colitis threw out green fluorescent colored feces, and with the result, it proved that without any invasive and expensive methods, a positive diagnosis can be achieved through this new method. The team also scrutinized the severity of the inflammation by examining the amount of green fluorescent proteins present in the poop. This also clarified that the sensor can also sense the severity of the disease.
Though it is still not cleared that thiosulfate acts as a biomarker for human colitis or not but the team seeks to develop this therapy for Human patients in the future.