Imitation of female reproductive system in a microfluidic device

Drugs are metabolized in a different way in females in comparison to males; however, females have been inadequately represented in drug studies. The reasonable concerns regarding the unfavorable influence of drug tests that can be experienced by a woman who is or can get pregnant have held them back from taking part in trials. But the dissimilarities between males and females in terms of physiology have restrained researchers in their capability to precisely guess how effective or safe a drug will be in females.

A research team from Draper and the Northwestern University has designed a small laboratory replica of a female reproductive tract. It is the dimension of a smart tablet and can ultimately alter the future of treatment and research of diseases in the reproductive organs of women.

The device is similar to a tiny well plate and consists of three-dimensional tissue models of fallopian tubes, ovaries, cervix, liver, and the uterus with unique fluid, which does several of the functions of blood, driving through all the organs. The organ models are capable of interacting with each other through released substances, such as hormones, to strongly represent how they all function collectively in the body.

On 28-day duration, an egg and hormones are released by the ovary and then passed through the fallopian tube to the uterus, all of it seen a tiny crystal clear car engine. The system’s other parts also consist of human cells mimicking that organ type and are linked to others similarly as in the body of a female.

By producing a microfluidic device that consists of living human cells competent of reproducing organ-level roles, Draper intends to enhance the approach of testing new drugs to offer cost-effective and more precise outcomes that do not have the ability to injury the fetuses or mothers. The system will assist researchers to comprehend diseases such as cancer, endometriosis, and fibroids.

Thus, the device will optimistically aid in identifying which potential drug substances will be not safe for pregnant women. It may also be helpful in further designing large-scale organ-on-chip techniques that will better signify the huge intricacy of the human body.